Dr David Sumpton
- Honorary Senior Lecturer (School of Cancer Sciences)
Publications
2026
Helgason, V. et al. (2026) Metabolism-specific drug-repurposing screen reveals itraconazole as a potent OXPHOS inhibitor in acute myeloid leukaemia. Blood, (Accepted for Publication)
2025
Gajic, N. et al. (2025) Selenocysteine Dependency Renders Central Nervous System Leukaemia Therapeutically Sensitive to Ferroptosi. 67th American Society of Hematology Annual Meeting, Orlando, USA, 06-09 Dec 2025. (doi: 10.1182/blood-2025-1526)
Gajic, N. et al. (2025) NADPH Controls a Cell State Vulnerability Towards Ferroptosis in Acute Lymphoblastic Leukaemia. 67th American Society of Hematology Annual Meeting, Orlando, USA, 06-09 Dec 2025. p. 144. (doi: 10.1182/blood-2025-144)
Boscenco, S. et al. (2025) Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer. Nature Genetics, 57(11), pp. 2705-2714. (doi: 10.1038/s41588-025-02374-0) (PMID:41184543) (PMCID:PMC12597822)
Whyte, D. et al. (2025) Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes. EMBO Reports, 26(17), pp. 4248-4282. (doi: 10.1038/s44319-025-00520-7) (PMID:40702342) (PMCID:PMC12420820)
Gounis, M. et al. (2025) Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments. Journal of Cell Biology, 224(8), e202405061. (doi: 10.1083/jcb.202405061) (PMID:40488669) (PMCID:PMC12147664)
2024
Kiourtis, C. et al. (2024) Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nature Cell Biology, 26(12), pp. 2075-2083. (doi: 10.1038/s41556-024-01543-3) (PMID:39537753) (PMCID:PMC11628396)
Jans, M. et al. (2024) Colibactin-driven colon cancer requires adhesin-mediated epithelial binding. Nature, 635(8038), pp. 472-480. (doi: 10.1038/s41586-024-08135-z) (PMID:39506107)
Khalaf, A. et al. (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16(751), eadi5336. (doi: 10.1126/scitranslmed.adi5336) (PMID:38865484)
Zarou, M. M. et al. (2024) Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1-mediated purine sensing. Nature Communications, 15, 1931. (doi: 10.1038/s41467-024-46114-0) (PMID:38431691) (PMCID:PMC10908830)
Articles
Helgason, V. et al. (2026) Metabolism-specific drug-repurposing screen reveals itraconazole as a potent OXPHOS inhibitor in acute myeloid leukaemia. Blood, (Accepted for Publication)
Boscenco, S. et al. (2025) Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer. Nature Genetics, 57(11), pp. 2705-2714. (doi: 10.1038/s41588-025-02374-0) (PMID:41184543) (PMCID:PMC12597822)
Whyte, D. et al. (2025) Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes. EMBO Reports, 26(17), pp. 4248-4282. (doi: 10.1038/s44319-025-00520-7) (PMID:40702342) (PMCID:PMC12420820)
Gounis, M. et al. (2025) Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments. Journal of Cell Biology, 224(8), e202405061. (doi: 10.1083/jcb.202405061) (PMID:40488669) (PMCID:PMC12147664)
Kiourtis, C. et al. (2024) Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nature Cell Biology, 26(12), pp. 2075-2083. (doi: 10.1038/s41556-024-01543-3) (PMID:39537753) (PMCID:PMC11628396)
Jans, M. et al. (2024) Colibactin-driven colon cancer requires adhesin-mediated epithelial binding. Nature, 635(8038), pp. 472-480. (doi: 10.1038/s41586-024-08135-z) (PMID:39506107)
Khalaf, A. et al. (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16(751), eadi5336. (doi: 10.1126/scitranslmed.adi5336) (PMID:38865484)
Zarou, M. M. et al. (2024) Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1-mediated purine sensing. Nature Communications, 15, 1931. (doi: 10.1038/s41467-024-46114-0) (PMID:38431691) (PMCID:PMC10908830)
Conference or Workshop Item
Gajic, N. et al. (2025) Selenocysteine Dependency Renders Central Nervous System Leukaemia Therapeutically Sensitive to Ferroptosi. 67th American Society of Hematology Annual Meeting, Orlando, USA, 06-09 Dec 2025. (doi: 10.1182/blood-2025-1526)
Gajic, N. et al. (2025) NADPH Controls a Cell State Vulnerability Towards Ferroptosis in Acute Lymphoblastic Leukaemia. 67th American Society of Hematology Annual Meeting, Orlando, USA, 06-09 Dec 2025. p. 144. (doi: 10.1182/blood-2025-144)