Projects and Services
The INCISE project - INtegrated TeChnologies for Improved Polyp SurveillancE – is a University of Glasgow-led collaboration with NHS Greater Glasgow and Clyde, Canon Medical Research, BioClavis and OracleBio, which aims to transform bowel cancer screening in the UK by developing a tool that can predict which patients with pre-cancerous growths in their bowels, called polyps, will develop further polyps.
The Inflammatory Signalling Group focuses on translational research. We investigate the role of inflammatory signaling on both tumour tissue and its surrounding microenvironment in colorectal cancer. By utilising multiplex staining, molecular techniques, 3D tissue culture and transcriptomics, we aim to identify novel prognostic and diagnostic biomarkers, unveil mechanisms underlying the regulations of tumor progression and immune tolerance, and develop new drugs for precision medicine.
The SCOT trial (ISRCTN59757862) was an “international, randomised, phase 3, non-inferiority trial” involving adult patients with high-risk stage II or stage III colorectal cancer. Patients received either 3 months or 6 months of adjuvant oxaliplatin-containing chemotherapy, consisting of CAPOX (capecitabine and oxaliplatin) or FOLFOX (bolus and infused fluorouracil with oxaliplatin).
TransSCOT is the translational arm of the SCOT trial, where samples of paraffin-embedded tumour tissue (obtained at surgical resection of SCOT patient’s primary tumour prior to entry into the trial) and blood samples (serum sample and EDTA sample) were collected as part of a sub-study research initiative.
The Glasgow Tissue Research Facility (GTRF) works in close collaboration with NHSGG&C Biorepository and provides researchers access to a wide variety of consented tissue, including:
- Pathology archive samples
- Surplus diagnostic or surgical tissue
- Bespoke collections of tissue from NHS Scotland patients may have been/or can be collected as part of cohort studies or clinical trials.