Mrs Karen Strathdee
- Affiliate- Prof Anthony Chalmers (School of Cancer Sciences)
email:
Karen.Strathdee@gla.systa-s.com
Wolfson Wohl Cancer Research Centre, Garscube Estate, Switchback Road, Bearsden
Publications
2026
Binner, P. et al. (2026) Wide-field and non-invasive imaging of brain tumours with scattered light techniques. Biomedical Optics Express, (Accepted for Publication)
2024
Derby, S. et al. (2024) Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis. Neuro-Oncology, 26(4), pp. 625-639. (doi: 10.1093/neuonc/noad210) (PMID:37936324) (PMCID:PMC10995506)
2022
Koessinger, A. L. et al. (2022) Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics. Cell Death and Differentiation, 29(10), pp. 2089-2104. (doi: 10.1038/s41418-022-01001-3) (PMID:35473984) (PMCID:PMC9525582)
Jackson, M. R. et al. (2022) Low-dose lung radiotherapy for COVID-19 lung disease: a preclinical efficacy study in a bleomycin model of pneumonitis. International Journal of Radiation Oncology, Biology, Physics, 112(1), pp. 197-211. (doi: 10.1016/j.ijrobp.2021.08.029) (PMID:34478832) (PMCID:PMC8406661)
2021
Birch, J. et al. (2021) Inhibition of ATR prevents macropinocytosis driven retraction of neurites and opposes invasion in GBM. Research Square, (doi: 10.21203/rs.3.rs-967109/v1) (PMID:37936324)
2020
Hanna, C. et al. (2020) Pharmacokinetics, safety and tolerability of olaparib and temozolomide for recurrent glioblastoma: results of the phase I OPARATIC trial. Neuro-Oncology, 22(12), pp. 1840-1850. (doi: 10.1093/neuonc/noaa104) (PMID:32347934) (PMCID:PMC7746945)
2018
Birch, J. L. et al. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78(22), pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697) (PMID:30279244)
Carruthers, R. D. et al. (2018) Replication stress drives constitutive activation of the DNA damage response and radioresistance in glioblastoma stem-like cells. Cancer Research, 78(17), pp. 5060-5071. (doi: 10.1158/0008-5472.CAN-18-0569) (PMID:29976574) (PMCID:PMC6128404)
2017
van de Lagemaat, L. N., Stanford, L. E., Pettit, C. M., Strathdee, D.J., Strathdee, K.E., Elsegood, K. A., Fricker, D. G., Croning, M. D. R., Komiyama, N. H. and Grant, S. G. N. (2017) Standardized experiments in mutant mice reveal behavioural similarity on 129S5 and C57BL/6J backgrounds. Genes, Brain and Behavior, 16(4), pp. 409-418. (doi: 10.1111/gbb.12364) (PMID:27886459)
2015
Carruthers, Ross 
ORCID: https://orcid.org/0000-0003-1077-6120, Ahmed, Shafiq U., Strathdee, Karen, Gomez-Roman, Natividad ORCID: https://orcid.org/0000-0002-2325-7517, Amoah-Buahin, Evelyn, Watts, Colin and Chalmers, Anthony J. ORCID: https://orcid.org/0000-0002-1746-7278
(2015)
Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase.
Molecular Oncology, 9(1),
pp. 192-203.
(doi: 10.1016/j.molonc.2014.08.003)
2014
Scopelliti, Alessandro, Cordero, Julia B., Diao, Fenqiu, Strathdee, Karen, White, Benjamin H., Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 and Vidal, Marcos
(2014)
Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut.
Current Biology, 24(11),
pp. 1199-1211.
(doi: 10.1016/j.cub.2014.04.007)
Lourenco, F.C. et al. (2014) Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation. Gut, 63(3), pp. 480-493. (doi: 10.1136/gutjnl-2012-303883)
Parisi, Federica, Stefanatos, Rhoda K., Strathdee, Karen, Yu, Yachuan and Vidal, Marcos (2014) Transformed epithelia trigger non-tissue-autonomous tumor suppressor response by adipocytes via activation of toll and Eiger/TNF signaling. Cell Reports, 6(5), pp. 855-867. (doi: 10.1016/j.celrep.2014.01.039)
2010
Cordero, J.B., Macagno, J.P., Stefanatos, R.K. ORCID: https://orcid.org/0000-0002-9072-7224, Strathdee, K.E., Cagan, R.L. and Vidal, M.
(2010)
Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter.
Developmental Cell, 18(6),
pp. 999-1011.
(doi: 10.1016/j.devcel.2010.05.014)
Articles
Binner, P. et al. (2026) Wide-field and non-invasive imaging of brain tumours with scattered light techniques. Biomedical Optics Express, (Accepted for Publication)
Derby, S. et al. (2024) Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis. Neuro-Oncology, 26(4), pp. 625-639. (doi: 10.1093/neuonc/noad210) (PMID:37936324) (PMCID:PMC10995506)
Koessinger, A. L. et al. (2022) Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics. Cell Death and Differentiation, 29(10), pp. 2089-2104. (doi: 10.1038/s41418-022-01001-3) (PMID:35473984) (PMCID:PMC9525582)
Jackson, M. R. et al. (2022) Low-dose lung radiotherapy for COVID-19 lung disease: a preclinical efficacy study in a bleomycin model of pneumonitis. International Journal of Radiation Oncology, Biology, Physics, 112(1), pp. 197-211. (doi: 10.1016/j.ijrobp.2021.08.029) (PMID:34478832) (PMCID:PMC8406661)
Birch, J. et al. (2021) Inhibition of ATR prevents macropinocytosis driven retraction of neurites and opposes invasion in GBM. Research Square, (doi: 10.21203/rs.3.rs-967109/v1) (PMID:37936324)
Hanna, C. et al. (2020) Pharmacokinetics, safety and tolerability of olaparib and temozolomide for recurrent glioblastoma: results of the phase I OPARATIC trial. Neuro-Oncology, 22(12), pp. 1840-1850. (doi: 10.1093/neuonc/noaa104) (PMID:32347934) (PMCID:PMC7746945)
Birch, J. L. et al. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78(22), pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697) (PMID:30279244)
Carruthers, R. D. et al. (2018) Replication stress drives constitutive activation of the DNA damage response and radioresistance in glioblastoma stem-like cells. Cancer Research, 78(17), pp. 5060-5071. (doi: 10.1158/0008-5472.CAN-18-0569) (PMID:29976574) (PMCID:PMC6128404)
van de Lagemaat, L. N., Stanford, L. E., Pettit, C. M., Strathdee, D.J., Strathdee, K.E., Elsegood, K. A., Fricker, D. G., Croning, M. D. R., Komiyama, N. H. and Grant, S. G. N. (2017) Standardized experiments in mutant mice reveal behavioural similarity on 129S5 and C57BL/6J backgrounds. Genes, Brain and Behavior, 16(4), pp. 409-418. (doi: 10.1111/gbb.12364) (PMID:27886459)
Carruthers, Ross ORCID: https://orcid.org/0000-0003-1077-6120, Ahmed, Shafiq U., Strathdee, Karen, Gomez-Roman, Natividad ORCID: https://orcid.org/0000-0002-2325-7517, Amoah-Buahin, Evelyn, Watts, Colin and Chalmers, Anthony J. ORCID: https://orcid.org/0000-0002-1746-7278
(2015)
Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase.
Molecular Oncology, 9(1),
pp. 192-203.
(doi: 10.1016/j.molonc.2014.08.003)
Scopelliti, Alessandro, Cordero, Julia B., Diao, Fenqiu, Strathdee, Karen, White, Benjamin H., Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 and Vidal, Marcos
(2014)
Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut.
Current Biology, 24(11),
pp. 1199-1211.
(doi: 10.1016/j.cub.2014.04.007)
Lourenco, F.C. et al. (2014) Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation. Gut, 63(3), pp. 480-493. (doi: 10.1136/gutjnl-2012-303883)
Parisi, Federica, Stefanatos, Rhoda K., Strathdee, Karen, Yu, Yachuan and Vidal, Marcos (2014) Transformed epithelia trigger non-tissue-autonomous tumor suppressor response by adipocytes via activation of toll and Eiger/TNF signaling. Cell Reports, 6(5), pp. 855-867. (doi: 10.1016/j.celrep.2014.01.039)
Cordero, J.B., Macagno, J.P., Stefanatos, R.K. ORCID: https://orcid.org/0000-0002-9072-7224, Strathdee, K.E., Cagan, R.L. and Vidal, M.
(2010)
Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter.
Developmental Cell, 18(6),
pp. 999-1011.
(doi: 10.1016/j.devcel.2010.05.014)