School of Infection & Immunity

Dr Enock Mararo

  • Research Associate (Immunology & Infection)

Biography

I am a Research Associate within the School of Infection & Immunity, where my work focuses on the cellular "conversations" that drive chronic inflammation and ageing.

My research journey began with a PhD in Veterinary Parasitology at the University of Edinburgh, investigating the metabolic "tug-of-war" between hosts and pathogens. Today, I apply that expertise to human health, specifically looking at how fibroblasts and immune cells interact in ageing tissues. By integrating multi-omic data—from single-cell RNA sequencing to metabolomics—I aim to identify new molecular pathways for treating immune-mediated inflammatory diseases.

Currently, I work across two research groups, supervised by Dr Chris Mahony (80%) and Professor Julia Edgar (20%), bridging the gap between basic discovery science and clinical applications in neuroimmunology.

Research interests

My research aims to understand how the immune system and structural cells (fibroblasts) change as we age. Key areas of focus include:

  • Cellular Interactions: Understanding how fibroblasts and immune cells communicate during chronic inflammation.

  • Multi-omics Integration: Using RNA-seq, scRNA-seq, and metabolomics to map complex host-pathogen and immune responses.

  • Immunometabolism: Investigating the metabolic mechanisms that underpin inflammatory disease.

  • Advanced Imaging: Applying confocal microscopy to visualize cellular behavior and tissue repair.

Publications

Prior publications

Article

Michael Harrison et al. (2026) Simplifying principles that underlie the highly complex peptide motif of the promiscuous chicken class I molecule, BF2*21:01 Crossref. (doi: 10.64898/2026.02.20.707067)

Enock M. Mararo, Anastasia Goryanin, Jim Kaufman (2025) Can the simple chicken MHC provide insight into the balance of autoimmunity and infectious disease? Immunogenetics Crossref. (doi: 10.1007/s00251-025-01394-8)

Omar A. Alfituri, Enock M. Mararo, Pieter C. Steketee, Liam J. Morrison, Neil A. Mabbott (2021) Dermal bacterial LPS-stimulation reduces susceptibility to intradermal Trypanosoma brucei infection Scientific Reports Crossref Metadata Search. ISSN 2045-2322 (doi: 10.1038/s41598-021-89053-2)

Godfrey Nattoh, Tushar Kanti Dutta, Joel L. Bargul, Gabriel Magoma, Lilian Mbaisi, Hellen Butungi, Enock Mararo, Evan Teal, Jeremy Keith Herren (2021) The fungus Leptosphaerulina persists in Anopheles gambiae and induces melanization PLOS ONE Crossref. (doi: 10.1371/journal.pone.0246452)

(2021) Tsetse blood-meal sources, endosymbionts and trypanosome-associations in the Maasai Mara National Reserve, a wildlife-human-livestock interface PLoS Negl Trop Dis Enock Mararo. (doi: 10.1371/journal.pntd.0008267)

Enock Mukibetti Mararo, Lilian Mbaisi, Edward Makhulu Edmond, Massimo Caine (2021) The Trojan mosquito: an in-house parasite defends against malaria TheScienceBreaker Crossref Metadata Search. ISSN 2571-9262 (doi: 10.25250/thescbr.brk459)

Hannah W. Karuri, Daniel Olago, Roy Neilson, Enock Mararo, Jandouwe Villinger (2017) A survey of root knot nematodes and resistance to Meloidogyne incognita in sweet potato varieties from Kenyan fields Crop Protection Crossref. (doi: 10.1016/j.cropro.2016.10.020)

Yvonne Ukamaka Ajamma, Enock Mararo, David Omondi, Thomas Onchuru, Anne W. T. Muigai, Daniel Masiga, Jandouwe Villinger (2016) Rapid and high throughput molecular identification of diverse mosquito species by high resolution melting analysis [version 1; referees: awaiting peer review] F1000. (doi: 10.12688/f1000research.9224.1)

Teaching

I am passionate about research-led teaching and supporting students as they develop their technical and analytical skills. My experience includes:

  • BVMS Level 1: Tutorial Instructor for fundamental cell biology (Royal (Dick) School of Veterinary Studies, University of Edinburgh).

  • Undergraduate & Postgraduate Mentorship: Providing hands-on supervision and technical training for students across several disciplines, specifically focusing on:

    • Advanced Imaging: Training in confocal and fluorescence microscopy.

    • Molecular Techniques: Guidance in parasite culture and molecular cloning.

    • Bioinformatics: Leading workshops on RNA-seq and scRNA-seq analysis workflows.