School of Molecular Biosciences

Dr Sakharam Waghmare

  • Research Associate (Molecular Biosciences)

telephone: 01413302381
email: Sakharam.Waghmare@gla.systa-s.com

Stevenson Lab, Institute of MC&SB, Bower Building

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-1918-0673

Biography

Sak comes from a background in the pharmaceutical-biotechnology industry and doctoral training in chemical and biological engineering. He has a PhD in Chemical Engineering from the University of Sheffield, where he developed and utilised RNA HPLC and quantitative RNA-mass spectrometry to study crRNA biogenesis in CRISPR/Cas complex in different bacterial systems.
Sak moved to the plant science lab at the University of Glasgow (2013) and has since perused research to address transport protein complexes underpinning plant environment sensing. In addition to his scientific work, he contributes to Plant Science public engagement initiatives through two cross-disciplinary STEM projects, StomaToy and Sci-Seedlets, to enhance plant science awareness in communities and school children.

Research interests

Plants have evolved a complex membrane traffic system that utilises membrane vesicles to facilitate intracellular transport, protein recycling, and secretion of signalling molecules for growth and defence. I study the underpinning molecular mechanisms of this system through multi-disciplinary approaches, including cell biology, protein biochemistry, mass spectrometry, structural biology, and plant physiology.

Currently, I am investigating 1) SNARE-dependent secretory pathways and their significance in environmental stresses and evolution, and 2) endolysosomal dynamics and their impact on phytohormones and CO2 response.

 

Publications

List by: Type | Date

Jump to: 2026 | 2025 | 2024 | 2022 | 2019 | 2018 | 2017 | 2015 | 2011 | 2009
Number of items: 16.

2026

Xia, L. et al. (2026) A guard cell carbonic anhydrase binds and regulates SLAC1 separate from its catalytic activity. Nature Communications, (doi: 10.1038/s41467-026-70596-9) (PMID:41826311) (Early Online Publication)

2025

Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Xia, Lingfeng ORCID logoORCID: https://orcid.org/0000-0002-8628-8062, McGill, Suzanne, Burchmore, Richard ORCID logoORCID: https://orcid.org/0000-0003-1663-9004 and Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099 (2025) Quantitative analysis of the arabidopsis leaf secretory proteome using via TMT- based mass spectrometry. Bio-protocol, 15(22), e5508. (doi: 10.21769/BioProtoc.5508)

Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Xia, Lingfeng ORCID logoORCID: https://orcid.org/0000-0002-8628-8062, Phan Ly, Thu, Xu, Jing, Farami, Sahar, Burchmore, Richard ORCID logoORCID: https://orcid.org/0000-0003-1663-9004, Blatt, Michael R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 and Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099 (2025) SYNTAXIN OF PLANTS 132 underpins secretion of cargoes associated with salicylic acid signaling and pathogen defense. Plant Physiology, 197(1), kiae541. (doi: 10.1093/plphys/kiae541) (PMID:39387490) (PMCID:PMC11663556)

2024

Baena, Guillermo ORCID logoORCID: https://orcid.org/0000-0003-3559-2862, Xia, Lingfeng ORCID logoORCID: https://orcid.org/0000-0002-8628-8062, Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Yu, ZhiYi, Guo, Yue, Blatt, Michael R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645, Zhang, Ben ORCID logoORCID: https://orcid.org/0000-0003-4473-9184 and Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099 (2024) Arabidopsis SNARE SYP132 impacts on PIP2;1 trafficking and function in salinity stress. Plant Journal, 118(4), pp. 1036-1053. (doi: 10.1111/tpj.16649) (PMID:38289468)

2022

Horaruang, W. et al. (2022) Engineering a K+ channel 'sensory antenna' enhances stomatal kinetics, water use efficiency and photosynthesis. Nature Plants, 8(11), pp. 1262-1274. (doi: 10.1038/s41477-022-01255-2) (PMID:36266492)

Baena, Guillermo ORCID logoORCID: https://orcid.org/0000-0003-3559-2862, Xia, Lingfeng ORCID logoORCID: https://orcid.org/0000-0002-8628-8062, Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673 and Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099 (2022) SNARE SYP132 mediates divergent trafficking of H+-ATPase AHA1 and antimicrobial PR1 during bacterial pathogenesis. Plant Physiology, 189(3), pp. 1639-1661. (doi: 10.1093/plphys/kiac149) (PMID:35348763) (PMCID:PMC9237740)

2019

Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Lefoulon, Cecile ORCID logoORCID: https://orcid.org/0000-0002-1131-3710, Zhang, Ben ORCID logoORCID: https://orcid.org/0000-0003-4473-9184, Lileikyte, Edita, Donald, Naomi and Blatt, Michael ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 (2019) K+ channel and SEC11 binding exchange regulates SNARE assembly for secretory traffic. Plant Physiology, 181, pp. 1096-1113. (doi: 10.1104/pp.19.00919) (PMID:31548266)

2018

Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Lileikyte, Edita, Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099, Goodman, Jennifer K., Blatt, Michael R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 and Jones, Alexandra M.E. (2018) SNAREs SYP121 and SYP122 mediate the secretion of distinct cargo subsets. Plant Physiology, 178(4), pp. 1679-1688. (doi: 10.1104/pp.18.00832) (PMID:30348815)

Lefoulon, Cecile ORCID logoORCID: https://orcid.org/0000-0002-1131-3710, Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099 and Blatt, Michael R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 (2018) Gating control and K+ uptake by the KAT1 K+ channel leaveraged through membrane anchoring of the trafficking protein SYP121. Plant, Cell and Environment, 41(11), pp. 2668-2677. (doi: 10.1111/pce.13392) (PMID:29940699) (PMCID:PMC6220998)

2017

Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099, Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Zhang, Ben ORCID logoORCID: https://orcid.org/0000-0003-4473-9184, Larson, Emily, Lefoulon, Cécile ORCID logoORCID: https://orcid.org/0000-0002-1131-3710, Gonzalez, Wendy and Blatt, Michael R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 (2017) Commandeering channel voltage sensors for secretion, cell turgor, and volume control. Trends in Plant Science, 22(1), pp. 81-95. (doi: 10.1016/j.tplants.2016.10.006) (PMID:27818003) (PMCID:PMC5224186)

Zhang, Ben ORCID logoORCID: https://orcid.org/0000-0003-4473-9184, Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099, Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Donald, Naomi Alice and Blatt, Mike R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 (2017) VAMP721 conformations unmask an extended motif for K+ channel binding and gating control. Plant Physiology, 173(1), pp. 536-551. (doi: 10.1104/pp.16.01549) (PMID:27821719)

2015

Grefen, Christopher, Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099, Larson, Emily, Lefoulon, Cecile ORCID logoORCID: https://orcid.org/0000-0002-1131-3710, Wang, Yizhou, Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Zhang, Ben ORCID logoORCID: https://orcid.org/0000-0003-4473-9184, Hills, Adrian and Blatt, Michael R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 (2015) A vesicle-trafficking protein commandeers Kv channel voltage sensors for voltage-dependent secretion. Nature Plants, 1, 15108. (doi: 10.1038/nplants.2015.108)

Waghmare, Sakharam P. ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Nwokeoji, Alison O. and Dickman, Mark J. (2015) Analysis of crRNA using liquid chromatography electrospray ionization mass spectrometry (LC ESI MS). In: Lundgren, Magnus, Charpentier, Emmanuelle and Fineran, Peter C. (eds.) CRISPR: Methods and Protocols. Series: Methods in molecular biology. Humana Press: New York, pp. 133-145. ISBN 9781493926879 (doi: 10.1007/978-1-4939-2687-9_8)

Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099, Zhang, Ben ORCID logoORCID: https://orcid.org/0000-0003-4473-9184, Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Aderhold, Christin, Grefen, Christopher and Blatt, Michael R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 (2015) Binding of SEC11 indicates its role in SNARE recycling after vesicle fusion and identifies two pathways for vesicular traffic to the plasma membrane. Plant Cell, 27(3), pp. 675-694. (doi: 10.1105/tpc.114.134429) (PMID:25747882)

2011

Wiedenheft, B. et al. (2011) RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions. Proceedings of the National Academy of Sciences of the United States of America, 108(25), pp. 10092-10097. (doi: 10.1073/pnas.1102716108) (PMID:21536913) (PMCID:PMC3121849)

2009

Waghmare, Sakharam P. ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Pousinis, Petros, Hornby, David P. and Dickman, Mark J. (2009) Studying the mechanism of RNA separations using RNA chromatography and its application in the analysis of ribosomal RNA and RNA:RNA interactions. Journal of Chromatography A, 1216(9), pp. 1377-1382. (doi: 10.1016/j.chroma.2008.12.077) (PMID:19155018)

This list was generated on Sat Apr 4 03:55:38 2026 BST.
Jump to: Articles | Book Sections
Number of items: 16.

Articles

Xia, L. et al. (2026) A guard cell carbonic anhydrase binds and regulates SLAC1 separate from its catalytic activity. Nature Communications, (doi: 10.1038/s41467-026-70596-9) (PMID:41826311) (Early Online Publication)

Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Xia, Lingfeng ORCID logoORCID: https://orcid.org/0000-0002-8628-8062, McGill, Suzanne, Burchmore, Richard ORCID logoORCID: https://orcid.org/0000-0003-1663-9004 and Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099 (2025) Quantitative analysis of the arabidopsis leaf secretory proteome using via TMT- based mass spectrometry. Bio-protocol, 15(22), e5508. (doi: 10.21769/BioProtoc.5508)

Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Xia, Lingfeng ORCID logoORCID: https://orcid.org/0000-0002-8628-8062, Phan Ly, Thu, Xu, Jing, Farami, Sahar, Burchmore, Richard ORCID logoORCID: https://orcid.org/0000-0003-1663-9004, Blatt, Michael R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 and Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099 (2025) SYNTAXIN OF PLANTS 132 underpins secretion of cargoes associated with salicylic acid signaling and pathogen defense. Plant Physiology, 197(1), kiae541. (doi: 10.1093/plphys/kiae541) (PMID:39387490) (PMCID:PMC11663556)

Baena, Guillermo ORCID logoORCID: https://orcid.org/0000-0003-3559-2862, Xia, Lingfeng ORCID logoORCID: https://orcid.org/0000-0002-8628-8062, Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Yu, ZhiYi, Guo, Yue, Blatt, Michael R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645, Zhang, Ben ORCID logoORCID: https://orcid.org/0000-0003-4473-9184 and Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099 (2024) Arabidopsis SNARE SYP132 impacts on PIP2;1 trafficking and function in salinity stress. Plant Journal, 118(4), pp. 1036-1053. (doi: 10.1111/tpj.16649) (PMID:38289468)

Horaruang, W. et al. (2022) Engineering a K+ channel 'sensory antenna' enhances stomatal kinetics, water use efficiency and photosynthesis. Nature Plants, 8(11), pp. 1262-1274. (doi: 10.1038/s41477-022-01255-2) (PMID:36266492)

Baena, Guillermo ORCID logoORCID: https://orcid.org/0000-0003-3559-2862, Xia, Lingfeng ORCID logoORCID: https://orcid.org/0000-0002-8628-8062, Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673 and Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099 (2022) SNARE SYP132 mediates divergent trafficking of H+-ATPase AHA1 and antimicrobial PR1 during bacterial pathogenesis. Plant Physiology, 189(3), pp. 1639-1661. (doi: 10.1093/plphys/kiac149) (PMID:35348763) (PMCID:PMC9237740)

Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Lefoulon, Cecile ORCID logoORCID: https://orcid.org/0000-0002-1131-3710, Zhang, Ben ORCID logoORCID: https://orcid.org/0000-0003-4473-9184, Lileikyte, Edita, Donald, Naomi and Blatt, Michael ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 (2019) K+ channel and SEC11 binding exchange regulates SNARE assembly for secretory traffic. Plant Physiology, 181, pp. 1096-1113. (doi: 10.1104/pp.19.00919) (PMID:31548266)

Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Lileikyte, Edita, Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099, Goodman, Jennifer K., Blatt, Michael R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 and Jones, Alexandra M.E. (2018) SNAREs SYP121 and SYP122 mediate the secretion of distinct cargo subsets. Plant Physiology, 178(4), pp. 1679-1688. (doi: 10.1104/pp.18.00832) (PMID:30348815)

Lefoulon, Cecile ORCID logoORCID: https://orcid.org/0000-0002-1131-3710, Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099 and Blatt, Michael R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 (2018) Gating control and K+ uptake by the KAT1 K+ channel leaveraged through membrane anchoring of the trafficking protein SYP121. Plant, Cell and Environment, 41(11), pp. 2668-2677. (doi: 10.1111/pce.13392) (PMID:29940699) (PMCID:PMC6220998)

Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099, Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Zhang, Ben ORCID logoORCID: https://orcid.org/0000-0003-4473-9184, Larson, Emily, Lefoulon, Cécile ORCID logoORCID: https://orcid.org/0000-0002-1131-3710, Gonzalez, Wendy and Blatt, Michael R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 (2017) Commandeering channel voltage sensors for secretion, cell turgor, and volume control. Trends in Plant Science, 22(1), pp. 81-95. (doi: 10.1016/j.tplants.2016.10.006) (PMID:27818003) (PMCID:PMC5224186)

Zhang, Ben ORCID logoORCID: https://orcid.org/0000-0003-4473-9184, Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099, Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Donald, Naomi Alice and Blatt, Mike R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 (2017) VAMP721 conformations unmask an extended motif for K+ channel binding and gating control. Plant Physiology, 173(1), pp. 536-551. (doi: 10.1104/pp.16.01549) (PMID:27821719)

Grefen, Christopher, Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099, Larson, Emily, Lefoulon, Cecile ORCID logoORCID: https://orcid.org/0000-0002-1131-3710, Wang, Yizhou, Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Zhang, Ben ORCID logoORCID: https://orcid.org/0000-0003-4473-9184, Hills, Adrian and Blatt, Michael R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 (2015) A vesicle-trafficking protein commandeers Kv channel voltage sensors for voltage-dependent secretion. Nature Plants, 1, 15108. (doi: 10.1038/nplants.2015.108)

Karnik, Rucha ORCID logoORCID: https://orcid.org/0000-0001-6876-4099, Zhang, Ben ORCID logoORCID: https://orcid.org/0000-0003-4473-9184, Waghmare, Sakharam ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Aderhold, Christin, Grefen, Christopher and Blatt, Michael R. ORCID logoORCID: https://orcid.org/0000-0003-1361-4645 (2015) Binding of SEC11 indicates its role in SNARE recycling after vesicle fusion and identifies two pathways for vesicular traffic to the plasma membrane. Plant Cell, 27(3), pp. 675-694. (doi: 10.1105/tpc.114.134429) (PMID:25747882)

Wiedenheft, B. et al. (2011) RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions. Proceedings of the National Academy of Sciences of the United States of America, 108(25), pp. 10092-10097. (doi: 10.1073/pnas.1102716108) (PMID:21536913) (PMCID:PMC3121849)

Waghmare, Sakharam P. ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Pousinis, Petros, Hornby, David P. and Dickman, Mark J. (2009) Studying the mechanism of RNA separations using RNA chromatography and its application in the analysis of ribosomal RNA and RNA:RNA interactions. Journal of Chromatography A, 1216(9), pp. 1377-1382. (doi: 10.1016/j.chroma.2008.12.077) (PMID:19155018)

Book Sections

Waghmare, Sakharam P. ORCID logoORCID: https://orcid.org/0000-0003-1918-0673, Nwokeoji, Alison O. and Dickman, Mark J. (2015) Analysis of crRNA using liquid chromatography electrospray ionization mass spectrometry (LC ESI MS). In: Lundgren, Magnus, Charpentier, Emmanuelle and Fineran, Peter C. (eds.) CRISPR: Methods and Protocols. Series: Methods in molecular biology. Humana Press: New York, pp. 133-145. ISBN 9781493926879 (doi: 10.1007/978-1-4939-2687-9_8)

This list was generated on Sat Apr 4 03:55:38 2026 BST.

Supervision

  • Liu, Dongjiao
    Molecular Mechanisms of Stomatal Regulation in Plants