Mr Clement Regnault
- Biochemical Data Analyst (MVLS Research Facilities)
email:
Clement.Regnault@gla.systa-s.com
Room B3.08, Joseph Black Building, University of Glasgow Gilmorehill Campus, University Place, Glasgow, G128QQ
Publications
2026
Addington, E. et al. (2026) Catabolism of serine enantiomers represses enterohemorrhagic Escherichia coli virulence factors via modulation of the nitrogen stress response. Proceedings of the National Academy of Sciences, 123(12), e253291612. (doi: 10.1073/pnas.2532916123) (PMID:41849392)
2025
McCreath, Gordan, Regnault, Clément, Blackburn, Gavin J. 
ORCID: https://orcid.org/0000-0003-1037-6012, Daly, Rónán ORCID: https://orcid.org/0000-0002-1275-6820, Leanord, Alistair T., Whitfield, Phillip D. ORCID: https://orcid.org/0000-0002-0814-4119, Roe, Andrew J. ORCID: https://orcid.org/0000-0003-3698-6134, Davidson, Alan, Watson, Malcolm J. and Sim, Malcolm A. B.
(2025)
Metabolomics for the diagnosis of secondary infections in critically ill patients with COVID-19.
Critical Care Explorations, 7(11),
e1336.
(doi: 10.1097/CCE.0000000000001336)
(PMID:41195955)
(PMCID:PMC12594302)
Haines, L. R. et al. (2025) Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone. Science Translational Medicine, 17(791), eadr4827. (doi: 10.1126/scitranslmed.adr4827) (PMID:40138457)
Ilbeigi, K. et al. (2025) Discovery and development of an advanced lead for the treatment of African trypanosomiasis. ACS Infectious Diseases, 11(1), pp. 131-143. (doi: 10.1021/acsinfecdis.4c00472) (PMID:39665421)
2023
Simwela, N. V. et al. (2023) A conserved metabolic signature associated with response to fast-acting anti-malarial agents. Microbiology Spectrum, 11(6), e0397622. (doi: 10.1128/spectrum.03976-22) (PMID:37800971) (PMCID:PMC10714989)
Crozier, L. et al. (2023) CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence. Molecular Cell, 83(22), 4062-4077.e5. (doi: 10.1016/j.molcel.2023.10.016) (PMID:37977118)
Năstase, A.-M. et al. (2023) Alignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites. PLoS Neglected Tropical Diseases, 17(7), e0011133. (doi: 10.1371/journal.pntd.0011133) (PMID:37486920) (PMCID:PMC10399774)
2022
O'Brien, Á. C. et al. (2022) Using organic contaminants to constrain the terrestrial journey of the martian meteorite Lafayette. Astrobiology, 22(11), pp. 1351-1362. (doi: 10.1089/ast.2021.0180) (PMID:36264546) (PMCID:PMC9618387)
Apostolopoulou, Natalia G., Smeti, Evangelia, Lamorgese, Marta, Varkitzi, Ioanna, Whitfield, Phillip, Regnault, Clement and Spatharis, Sofie ORCID: https://orcid.org/0000-0003-1030-9821
(2022)
Microalgae show a range of responses to exometabolites of foreign species.
Algal Research, 62,
102627.
(doi: 10.1016/j.algal.2021.102627)
(PMID:35311224)
(PMCID:PMC8924005)
Rubić, I. et al. (2022) Multi platforms strategies and metabolomics approaches for the investigation of comprehensive metabolite profile in dogs with Babesia canis infection. International Journal of Molecular Sciences, 23(3), 1575. (doi: 10.3390/ijms23031575) (PMID:35163517) (PMCID:PMC8835742)
Jara, Marlene, Barrett, Michael ORCID: https://orcid.org/0000-0001-9447-3519, Maes, Ilse, Regnault, Clement, Imamura, Hideo, Domagalska, Malgorzata Anna and Dujardin, Jean-Claude
(2022)
Transcriptional shift and metabolic adaptations during Leishmania quiescence using stationary phase and drug pressure as models.
Microorganisms, 10(1),
97.
(doi: 10.3390/microorganisms10010097)
(PMID:35056546)
(PMCID:PMC8781126)
2021
Milne, K. et al. (2021) Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum. eLife, 10, e62800. (doi: 10.7554/elife.62800) (PMID:33648633) (PMCID:PMC7924948)
2020
Giordani, F. et al. (2020) Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs. PLoS Pathogens, 16(11), e1008932. (doi: 10.1371/journal.ppat.1008932) (PMID:33141865) (PMCID:PMC7710103)
Doleželová, Eva, Kunzová, Michaela, Dejung, Mario, Levin, Michal, Panicucci, Brian, Regnault, Clément, Janzen, Christian J., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Butter, Falk and Zíková, Alena
(2020)
Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei.
PLoS Biology, 18(6),
e3000741.
(doi: 10.1371/journal.pbio.3000741)
(PMID:32520929)
(PMCID:PMC7307792)
2019
Pountain, Andrew W. ORCID: https://orcid.org/0000-0001-9651-5145, Weidt, Stefan K., Regnault, Clément, Bates, Paul A., Donachie, Anne M., Dickens, Nicholas J. ORCID: https://orcid.org/0000-0003-0492-5855 and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519
(2019)
Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites.
PLoS Neglected Tropical Diseases, 13(2),
e0007052.
(doi: 10.1371/journal.pntd.0007052)
(PMID:30716073)
(PMCID:PMC6375703)
2018
Diaz-Albiter, Hector M., Regnault, Clément, Alpizar-Sosa, Edubiel A., McGuinness, Dagmara ORCID: https://orcid.org/0000-0001-9057-3504, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Dillon, Rod J.
(2018)
Non-invasive visualisation and identification of fluorescent.
Wellcome Open Research, 3,
160.
(doi: 10.12688/wellcomeopenres.14910.1)
(PMID:30756095)
(PMCID:PMC6367660)
Regnault, Clement, Dheeman, Dharmendra and Hochstetter, Axel ORCID: https://orcid.org/0000-0002-2791-2400
(2018)
Microfluidic devices for drug assays.
High-Throughput, 7(2),
18.
(doi: 10.3390/ht7020018)
(PMID:29925804)
(PMCID:29925804)
Rattigan, Kevin M., Pountain, Andrew W. ORCID: https://orcid.org/0000-0001-9651-5145, Regnault, Clement, Achcar, Fiona ORCID: https://orcid.org/0000-0001-8792-7615, Vincent, Isabel M. ORCID: https://orcid.org/0000-0003-2663-4389, Goodyear, Carl S. ORCID: https://orcid.org/0000-0001-5926-5941 and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519
(2018)
Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli.
PLoS ONE, 13(3),
e0194126.
(doi: 10.1371/journal.pone.0194126)
(PMID:29538444)
(PMCID:PMC5851634)
2017
Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Cooper, Jonathan M. ORCID: https://orcid.org/0000-0002-2358-1050, Regnault, Clément, Holm, Stefan H., Beech, Jason P., Tegenfeldt, Jonas O. and Hochstetter, Axel ORCID: https://orcid.org/0000-0002-2791-2400
(2017)
Microfluidics-based approaches to the isolation of African trypanosomes.
Pathogens, 6(4),
47.
(doi: 10.3390/pathogens6040047)
(PMID:28981471)
(PMCID:PMC5750571)
Articles
Addington, E. et al. (2026) Catabolism of serine enantiomers represses enterohemorrhagic Escherichia coli virulence factors via modulation of the nitrogen stress response. Proceedings of the National Academy of Sciences, 123(12), e253291612. (doi: 10.1073/pnas.2532916123) (PMID:41849392)
McCreath, Gordan, Regnault, Clément, Blackburn, Gavin J. ORCID: https://orcid.org/0000-0003-1037-6012, Daly, Rónán ORCID: https://orcid.org/0000-0002-1275-6820, Leanord, Alistair T., Whitfield, Phillip D. ORCID: https://orcid.org/0000-0002-0814-4119, Roe, Andrew J. ORCID: https://orcid.org/0000-0003-3698-6134, Davidson, Alan, Watson, Malcolm J. and Sim, Malcolm A. B.
(2025)
Metabolomics for the diagnosis of secondary infections in critically ill patients with COVID-19.
Critical Care Explorations, 7(11),
e1336.
(doi: 10.1097/CCE.0000000000001336)
(PMID:41195955)
(PMCID:PMC12594302)
Haines, L. R. et al. (2025) Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone. Science Translational Medicine, 17(791), eadr4827. (doi: 10.1126/scitranslmed.adr4827) (PMID:40138457)
Ilbeigi, K. et al. (2025) Discovery and development of an advanced lead for the treatment of African trypanosomiasis. ACS Infectious Diseases, 11(1), pp. 131-143. (doi: 10.1021/acsinfecdis.4c00472) (PMID:39665421)
Simwela, N. V. et al. (2023) A conserved metabolic signature associated with response to fast-acting anti-malarial agents. Microbiology Spectrum, 11(6), e0397622. (doi: 10.1128/spectrum.03976-22) (PMID:37800971) (PMCID:PMC10714989)
Crozier, L. et al. (2023) CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence. Molecular Cell, 83(22), 4062-4077.e5. (doi: 10.1016/j.molcel.2023.10.016) (PMID:37977118)
Năstase, A.-M. et al. (2023) Alignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites. PLoS Neglected Tropical Diseases, 17(7), e0011133. (doi: 10.1371/journal.pntd.0011133) (PMID:37486920) (PMCID:PMC10399774)
O'Brien, Á. C. et al. (2022) Using organic contaminants to constrain the terrestrial journey of the martian meteorite Lafayette. Astrobiology, 22(11), pp. 1351-1362. (doi: 10.1089/ast.2021.0180) (PMID:36264546) (PMCID:PMC9618387)
Apostolopoulou, Natalia G., Smeti, Evangelia, Lamorgese, Marta, Varkitzi, Ioanna, Whitfield, Phillip, Regnault, Clement and Spatharis, Sofie ORCID: https://orcid.org/0000-0003-1030-9821
(2022)
Microalgae show a range of responses to exometabolites of foreign species.
Algal Research, 62,
102627.
(doi: 10.1016/j.algal.2021.102627)
(PMID:35311224)
(PMCID:PMC8924005)
Rubić, I. et al. (2022) Multi platforms strategies and metabolomics approaches for the investigation of comprehensive metabolite profile in dogs with Babesia canis infection. International Journal of Molecular Sciences, 23(3), 1575. (doi: 10.3390/ijms23031575) (PMID:35163517) (PMCID:PMC8835742)
Jara, Marlene, Barrett, Michael ORCID: https://orcid.org/0000-0001-9447-3519, Maes, Ilse, Regnault, Clement, Imamura, Hideo, Domagalska, Malgorzata Anna and Dujardin, Jean-Claude
(2022)
Transcriptional shift and metabolic adaptations during Leishmania quiescence using stationary phase and drug pressure as models.
Microorganisms, 10(1),
97.
(doi: 10.3390/microorganisms10010097)
(PMID:35056546)
(PMCID:PMC8781126)
Milne, K. et al. (2021) Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum. eLife, 10, e62800. (doi: 10.7554/elife.62800) (PMID:33648633) (PMCID:PMC7924948)
Giordani, F. et al. (2020) Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs. PLoS Pathogens, 16(11), e1008932. (doi: 10.1371/journal.ppat.1008932) (PMID:33141865) (PMCID:PMC7710103)
Doleželová, Eva, Kunzová, Michaela, Dejung, Mario, Levin, Michal, Panicucci, Brian, Regnault, Clément, Janzen, Christian J., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Butter, Falk and Zíková, Alena
(2020)
Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei.
PLoS Biology, 18(6),
e3000741.
(doi: 10.1371/journal.pbio.3000741)
(PMID:32520929)
(PMCID:PMC7307792)
Pountain, Andrew W. ORCID: https://orcid.org/0000-0001-9651-5145, Weidt, Stefan K., Regnault, Clément, Bates, Paul A., Donachie, Anne M., Dickens, Nicholas J. ORCID: https://orcid.org/0000-0003-0492-5855 and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519
(2019)
Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites.
PLoS Neglected Tropical Diseases, 13(2),
e0007052.
(doi: 10.1371/journal.pntd.0007052)
(PMID:30716073)
(PMCID:PMC6375703)
Diaz-Albiter, Hector M., Regnault, Clément, Alpizar-Sosa, Edubiel A., McGuinness, Dagmara ORCID: https://orcid.org/0000-0001-9057-3504, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Dillon, Rod J.
(2018)
Non-invasive visualisation and identification of fluorescent.
Wellcome Open Research, 3,
160.
(doi: 10.12688/wellcomeopenres.14910.1)
(PMID:30756095)
(PMCID:PMC6367660)
Regnault, Clement, Dheeman, Dharmendra and Hochstetter, Axel ORCID: https://orcid.org/0000-0002-2791-2400
(2018)
Microfluidic devices for drug assays.
High-Throughput, 7(2),
18.
(doi: 10.3390/ht7020018)
(PMID:29925804)
(PMCID:29925804)
Rattigan, Kevin M., Pountain, Andrew W. ORCID: https://orcid.org/0000-0001-9651-5145, Regnault, Clement, Achcar, Fiona ORCID: https://orcid.org/0000-0001-8792-7615, Vincent, Isabel M. ORCID: https://orcid.org/0000-0003-2663-4389, Goodyear, Carl S. ORCID: https://orcid.org/0000-0001-5926-5941 and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519
(2018)
Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli.
PLoS ONE, 13(3),
e0194126.
(doi: 10.1371/journal.pone.0194126)
(PMID:29538444)
(PMCID:PMC5851634)
Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Cooper, Jonathan M. ORCID: https://orcid.org/0000-0002-2358-1050, Regnault, Clément, Holm, Stefan H., Beech, Jason P., Tegenfeldt, Jonas O. and Hochstetter, Axel ORCID: https://orcid.org/0000-0002-2791-2400
(2017)
Microfluidics-based approaches to the isolation of African trypanosomes.
Pathogens, 6(4),
47.
(doi: 10.3390/pathogens6040047)
(PMID:28981471)
(PMCID:PMC5750571)