School of Cancer Sciences

Head/Neck/Thyroid

Research by Glasgow Head & Neck Cancer Research Group (GLAHNC), with the primary aim of increasing research into head & neck cancer in Glasgow.

Staff

Publications

2026

Creaney, G., Lyra González, I., Cuello, M., de Aquino Goulart, M., McMahon, A. D., Paterson, C., McCaul, J., Popovic, M., Richiardi, L., Lopez de Blanc, S., Curado, M. P., Vilensky, M., HEADSpAcE Consortium, ., Alwaheidi, S., Brennan, P., Virani, S., Ross, A., Conway, D. I. (2026) Health system factors in head and neck cancer diagnosis: a HEADSpAcE consortium qualitative study in Glasgow and Montevideo. Head and Neck, (doi: 10.1002/hed.70262)

Centeno, P. P., Chester, C., Kanellos, G., Ford, C. A., Cammarezi, P., Inman, G. J., Jamieson, T., Ridgeway, R. A., Marais, R., Campbell, A. D., Sansom, O. J. (2026) SOX2 confers tumour permissiveness in a specific skin progenitor population. Nature Communications, 17, (doi: 10.1038/s41467-025-66251-4)

Smith, C. D.L., McMahon, A. D., Inman, G. J., Conway, D. I., Douglas, C. M., Paterson, C. (2026) The COVID-19 pandemic has not influenced survival outcomes of head and neck cancer squamous cell carcinomas in the West of Scotland: a retrospective cohort study. BJC Reports, 4, (doi: 10.1038/s44276-026-00203-3)

2025

Peters, A. L. et al. (2025) Involved neck only versus mucosal radiotherapy for head and neck squamous cell cancer of unknown primary (HNSCCUP): a national retrospective multicentre cohort study. International Journal of Radiation Oncology, Biology, Physics, (doi: 10.1016/j.ijrobp.2025.11.013)

Bone, M., Inman, G. J. (2025) Alternative transcription increases isoform complexity in Long Non-Coding RNAs and alters their functions in cancer. Non-coding RNA Research, 14, pp. 38-50. (doi: 10.1016/j.ncrna.2025.04.008)

Clements, K., Hurley, R., Conway, D. I., Paterson, C., Douglas, C. M. (2025) The changing profile of laryngeal cancer: a 20-year retrospective cohort analysis. European Archives of Oto-Rhino-Laryngology, 282, pp. 4795-4805. (doi: 10.1007/s00405-025-09500-y)

Bone, M., Schreyer, D., Treanor-Taylor, M., Proby, C., Harwood, C., Leigh, I. M., Bailey, P., Inman, G. (2025) The landscape of long noncoding RNA during cutaneous squamous cell carcinoma progression. British Journal of Dermatology, 193, pp. 490-501. (doi: 10.1093/bjd/ljaf108)

Chmielecka, M., Hurley, R., Mohd Slim, M. A., Philp, N., Donachie, M., Horackiewicz, J., McGovern, J., Knight, K., Rattray, N. J.W., Paterson, C., Douglas, C. M. (2025) Does Modified 5-Item Frailty Index correlate with survival in oropharyngeal squamous cell carcinoma? Head and Neck, (doi: 10.1002/hed.70005)

Inanc, B., Fang, Q., Roos, W. P., Andrews, J. F., Zeng, X., Clark, J., Li, J., Dey, N. B., Ibrahim, M., Sykora, P., Yu, Z., Pearson, C. R., Braganza, A., Verheij, M., Jonkers, J., Yates, N. A., Vens, C., Sobol, R. W. (2025) TRIP12's role in the governance of DNA polymerase β involvement in DNA damage response and repair. Nucleic Acids Research, 53, (doi: 10.1093/nar/gkaf574)

Creaney, G. et al. (2025) Advanced stage head and neck cancer diagnosis: HEADSpAcE Consortium health systems benchmarking survey. Head and Neck, 47, pp. 1977-1988. (doi: 10.1002/hed.28094)

Hurley, R., Paterson, C., Conway, D. I., Inman, G. J., Douglas, C. M. (2025) Laryngeal cancer in the West of Scotland 2014–2020: trends and survival in a cohort of 867 patients. Laryngoscope, 135, pp. 2051-2061. (doi: 10.1002/lary.31992)

Cartwright, D., Kidd, A. C., Ansel, S., Ascierto, M. L., Spiliopoulou, P. (2025) Oncogenic signalling pathways in cancer immunotherapy: leader or follower in this delicate dance? International Journal of Molecular Sciences, 26, (doi: 10.3390/ijms26094393)

Clements, K., McMahon, A. D., Bhatti, L., Smith, C., Paterson, C., Douglas, C. M., Conway, D. (2025) Incidence trends in head and neck cancer subsites: a national population-based study (2001-2020) Clinical Otolaryngology, 50, pp. 474-484. (doi: 10.1111/coa.14271)

Donachie, M., Horackiewicz, J., Philp, N., Slim, M. A. M., Hurley, R., Douglas, C. (2025) Oropharyngeal squamous cell carcinoma in the West of Scotland: a retrospective analysis of 1001 patients from 2012 to 2020. Clinical Otolaryngology, 50, pp. 573-581. (doi: 10.1111/coa.14282)

McCann, C., Hurley, R., McGovern, J., Knight, K., Rattray, N. J.W., Douglas, C. M. (2025) Frailty and the survival outcomes of patients with laryngeal squamous cell cancer. Head and Neck, 47, pp. 1079-1092. (doi: 10.1002/hed.27951)

Hurley, R., Osbourne, J., Inman, G. J., Conway, D. I., Paterson, C., Douglas, C. (2025) Pre-treatment serum prognostic scores and survival in curatively treated laryngeal cancer. Laryngoscope Investigative Otolaryngology, 10, (doi: 10.1002/lio2.70124)

White, S. E., Schwartze, T. A., Mukundan, A., Schoenherr, C., Singh, S. P., van Dinther, M., Cunningham, K. T., White, M. P. J., Campion, T., Pritchard, J., Hinck, C. S., ten Dijke, P., Inman, G. J., Maizels, R. M., Hinck, A. P. (2025) TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts. Nature Communications, 16, (doi: 10.1038/s41467-025-56954-z)

Singh, S. P., Smyth, D. J., Cunningham, K. T., Mukundan, A., Byeon, C.-H., Hinck, C. S., White, M. P.J., Ciancia, C., Wąsowska, N., Sanders, A., Jin, R., White, R. F., Lilla, S., Zanivan, S., Schoenherr, C., Inman, G., van Dinther, M., ten Dijke, P., Hinck, A. P., Maizels, R. M. (2025) The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding. EMBO Reports, 26, pp. 218-244. (doi: 10.1038/s44319-024-00323-2)

2024

Kiourtis, C. et al. (2024) Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nature Cell Biology, 26, pp. 2075-2083. (doi: 10.1038/s41556-024-01543-3)

Mactier, K., Baxter, M., Peters, A., Fair, K., Hannington, L., Robertson, J., Wood, G., Sarwar, A., Bishr, M., Webb, R., Al-Zubaidi, M., Eastlake, L., Lankester, K., McInerney, S., Creedon, H., Stillie, A., Purshouse, K. (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14, (doi: 10.1136/bmjopen-2024-094838)

Smith, C. D.L., McMahon, A. D., Purkayastha, M., Creaney, G., Clements, K., Inman, G. J., Bhatti, L. A., Douglas, C. M., Paterson, C., Conway, D. I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020) BJC Reports, 2, (doi: 10.1038/s44276-024-00089-z)

Strathearn, L. S., Spender, L. C., Schoenherr, C., Mason, S., Edwards, R., Blyth, K., Inman, G. (2024) C1orf106 (INAVA) is a SMAD3-dependent TGF-β target gene that promotes clonogenicity and correlates with poor prognosis in breast cancer. Cells, 13, (doi: 10.3390/cells13181530)

Smith, C. D.L., McMahon, A. D., Lyall, D. M., Goulart, M., Inman, G., Ross, A., Gormley, M., Dudding, T., Macfarlane, G. J., Robinson, M., Richiardi, L., Serraino, D., Polesel, J., Canova, C., Ahrens, W., Healy, C. M., Lagiou, P., Holcatova, I., Alemany, L., Znoar, A., Waterboer, T., Brennan, P., Virani, S., Conway, D. I. (2024) Development and external validation of a head and neck cancer risk prediction model. Head and Neck, 46, pp. 2261-2273. (doi: 10.1002/hed.27834)

Clements, K., Thapa, A., Cowell, A., Conway, D., Douglas, C. M., Paterson, C. (2024) Impact of the COVID-19 pandemic on stage and incidence of head and neck cancer: a rapid review and meta-analysis. Clinical Otolaryngology, 49, pp. 363-375. (doi: 10.1111/coa.14152)

Peters, A.L., Hall, P.S., Jordan, L.B., Soh, F.Y., Hannington, L., Makaranka, S., Urquhart, G., Vallet, M., Cartwright, D., Marashi, H., Elsberger, B. (2024) Enhancing clinical decision support with genomic tools in breast cancer: a Scottish perspective. Breast, 75, (doi: 10.1016/j.breast.2024.103728)

Thapa, A., Cowell, A., Peters, A., Noble, D. J., James, A., Lamb, C., Grose, D., Vohra, S., Schipani, S., Mactier, K., Mackenzie, J., Srinivasan, D., Laws, K., Moleron, R., Niblock, P., Soh, F.-Y., Paterson, C., Wilson, C. (2024) The UK Divide: Does having a Pembrolizumab-Chemotherapy option in head and neck cancer matter? Real-world experience of first-line palliative pembrolizumab monotherapy and pembrolizumab-chemotherapy combination in Scotland. Clinical Oncology, 36, pp. 287-299. (doi: 10.1016/j.clon.2024.02.004)

Vens, C., van Luijk, P., Vogelius, R.I., El Naqa, I., Humbert-Vidan, L., von Neubeck, C., Gomez-Roman, N., Bahn, E., Brualla, L., Böhlen, T.T., Ecker, S., Koch, R., Handeland, A., Pereira, S., Possenti, L., Rancati, T., Todor, D., Vanderstraeten, B., Van Heerden, M., Ullrich, W., Jackson, M., Alber, M., Marignol, L., ESTRO DREAM team, (2024) A joint physics and radiobiology DREAM team vision - towards better response prediction models to advance radiotherapy. Radiotherapy and Oncology, 196, (doi: 10.1016/j.radonc.2024.110277)

Ahmadian, M., Bodalal, Z., van der Hulst, H. J., Vens, C., Karssemakers, L. H.E., Bogveradze, N., Castagnoli, F., Landolfi, F., Hong, E. K., Gennaro, N., Pizzi, A. D., Beets-Tan, R. G.H., van den Brekel, M. W.M., Castelijns, J. A. (2024) Overcoming data scarcity in radiomics/radiogenomics using synthetic radiomic features. Computers in Biology and Medicine, 174, (doi: 10.1016/j.compbiomed.2024.108389)

Homer, J. J. et al. (2024) Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition. Journal of Laryngology and Otology, 138, pp. S1-S224. (doi: 10.1017/S0022215123001615)

Derby, S. et al. (2024) Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis. Neuro-Oncology, 26, pp. 625-639. (doi: 10.1093/neuonc/noad210)

2023

Wang, J., Harwood, C. A., Bailey, E., Bewicke-Copley, F., Anene, C. A., Thomson, J., Qamar, M. J., Laban, R., Nourse, C., Schoenherr, C., Treanor-Taylor, M., Healy, E., Lai, C., Craig, P., Moyes, C., Rickaby, W., Martin, J., Proby, C., Inman, G. J., Leigh, I. M. (2023) Transcriptomic analysis of cutaneous squamous cell carcinoma reveals a multigene prognostic signature associated with metastasis. Journal of the American Academy of Dermatology, 89, pp. 1159-1166. (doi: 10.1016/j.jaad.2023.08.012)

Neilson, L. J., Cartwright, D., Risteli, M., Jokinen, E. M., McGarry, L., Sandvik, T., Nikolatou, K., Hodge, K., Atkinson, S., Vias, M., Kay, E. J., Brenton, J. D., Carlin, L. M., Bryant, D. M., Salo, T., Zanivan, S. (2023) Omentum-derived matrix enables the study of metastatic ovarian cancer and stromal cell functions in a physiologically relevant environment. Matrix Biology Plus, 19-20, (doi: 10.1016/j.mbplus.2023.100136)

Van der Hulst, H. J., Jansen, R. W., Vens, C., Bos, P., Schats, W., De Jong, M. C., Martens, R. M., Bodalal, Z., Beets-Tan, R. G. H., Van den Brekel, M. W. M., De Graaf, P., Castelijns, J. A. (2023) The prediction of biological features using magnetic resonance imaging in head and neck squamous cell carcinoma: a systematic review and meta-analysis. Cancers, 15, (doi: 10.3390/cancers15205077)

Lim, A. E., Hurley, R., Slim, M. A. M., Melia, L. (2023) A narrative review of flutamide in juvenile nasopharyngeal angiofibroma. Indian Journal of Otolaryngology and Head and Neck Surgery, 75, pp. 2707-2712. (doi: 10.1007/s12070-023-03581-z)

Bailey, P., Ridgway, R. L., Cammareri, P., Treanor-Taylor, M., Bailey, U.-M., Schoenherr, C., Bone, M., Schreyer, D., Purdie, K., Thomson, J., Rickaby, W., Jackstadt, R., Campbell, A. D., Dimonitsas, E., Stratigos, A. J., Arron, S. T., Wang, J., Blyth, K., Proby, C. M., Harwood, C. A., Sansom, O. J., Leigh, I. M., Inman, G. J. (2023) Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression. Nature Communications, 14, (doi: 10.1038/s41467-023-40822-9)

Clements, K., Cowell, A., White, G., Flynn, W., Conway, D. I., Douglas, C. M., Paterson, C. (2023) The COVID-19 pandemic has not changed stage at presentation nor treatment patterns of head and neck cancer: a retrospective cohort study. Clinical Otolaryngology, 48, pp. 587-594. (doi: 10.1111/coa.14048)

Alizzi, Z., Roxburgh, P., Cartwright, D., McLaren, A., Park, S., Jones, R., Greening, S., Hudson, E., Green, C., Gray, S., Khalique, S., Karteris, E., Hall, M. (2023) Description of a retrospective cohort of epithelial ovarian cancer patients with brain metastases: evaluation of the role of PARP inhibitors in this setting. Journal of Clinical Medicine, 12, (doi: 10.3390/jcm12072497)

Hay, L. K., McLoone, P., Borgaonkar, S., Schipani, S., Wilson, C., Grose, D., James, A., Lamb, C., Paterson, C. (2023) Can elderly patients be safely selected for head and neck radiotherapy without formal geriatric or frailty assessment: a retrospective cohort study. Clinical Otolaryngology, 48, pp. 240-244. (doi: 10.1111/coa.14005)

Poon, W.-Y., Paterson, C., McLoone, P., Grose, D., Schipani, S., Lamb, C., James, A., Wilson, C. (2023) Survival outcomes in hypopharyngeal cancer in the West of Scotland Cancer Network. Clinical Otolaryngology, 48, pp. 235-239. (doi: 10.1111/coa.14003)

2022

Flanagan, D. J. et al. (2022) Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features. Nature Communications, 13, (doi: 10.1038/s41467-022-35134-3)

Smith, C., McMahon, A. D., Ross, A., Inman, G. J., Conway, D. I. (2022) Risk prediction models for head and neck cancer: a rapid review. Laryngoscope Investigative Otolaryngology, 7, pp. 1893-1908. (doi: 10.1002/lio2.982)

Creaney, G., McMahon, A. D., Ross, A. J., Bhatti, L. A., Paterson, C., Conway, D. I. (2022) Head and neck cancer in the UK: what was the stage before COVID-19? UK cancer registries analysis (2011-2018) British Dental Journal, 233, pp. 787-793. (doi: 10.1038/s41415-022-5151-4)

Gormley, M., Creaney, G., Schache, A., Ingarfield, K., Conway, D. I. (2022) Reviewing the epidemiology of head and neck cancer: definitions, trends and risk factors. British Dental Journal, 233, pp. 780-786. (doi: 10.1038/s41415-022-5166-x)

van der Wiel, A. M. A., Schuitmaker, L., Cong, Y., Theys, J., Van Hoeck, A., Vens, C., Lambin, P., Yaromina, A., Dubois, L. J. (2022) Homologous recombination deficiency scar: mutations and beyond—implications for precision oncology. Cancers, 14, (doi: 10.3390/cancers14174157)

Zhou, S., Chan, C., Rulach, R., Dyab, H., Hendry, F., Maxfield, C., Dempsey, M.-F., James, A., Grose, D., Lamb, C., Schipani, S., Wilson, C., Cheng Lau, Y., Paterson, C. (2022) Long term survival in patients with human papillomavirus-positive oropharyngeal cancer and equivocal response on 12-week PET-CT is not compromised by the omission of neck dissection. Oral Oncology, 128, (doi: 10.1016/j.oraloncology.2022.105870)

Grocutt, L., Paterson, C., Valentine, R. M. (2022) Adaptive dose escalated radiotherapy in oropharyngeal cancers: a treatment planning feasibility study. Radiation Oncology, 17, (doi: 10.1186/s13014-022-01991-x)

2021

Hollis, R. L., Stillie, L. J., Hopkins, S., Bartos, C., Churchman, M., Rye, T., Nussey, F., Fegan, S., Nirsimloo, R., Inman, G. J., Herrington, C. S., Gourley, C. (2021) Clinicopathological determinants of recurrence risk and survival in mucinous ovarian carcinoma. Cancers, 13, (doi: 10.3390/cancers13225839)

Birch, J., Strathdee, K., Stevenson, K., Derby, S., Dutton, L., Clough, E., Koessinger, A., Gilmour, L., McGhee, E., McGarrity-Cottrell, C., Dibekeme, A. a., Collis, S., Rominiyi, O., Lembruber Soares, L., Solecki, G., Winkler, F., Carlin, L., Inman, G., Chalmers, A., Norman, J., Carruthers, R. (2021) Inhibition of ATR prevents macropinocytosis driven retraction of neurites and opposes invasion in GBM. Research Square, (doi: 10.21203/rs.3.rs-967109/v1)

Leach, J. D.G. et al. (2021) Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis. Nature Communications, 12, (doi: 10.1038/s41467-021-23717-5)

2020

Poon, W.-Y., Thomson, M., McLoone, P., Wilson, C., Crosbie, R., Schipani, S., Grose, D., James, A., Lamb, C., Rizwanullah, M., Campbell, F., Easton, F., Paterson, C. (2020) Comparative cohort study of volumetric modulated arc therapy for squamous cell cancer of unknown primary in the head and neck-involved neck only versus mucosal irradiation. Clinical Otolaryngology, 45, pp. 847-852. (doi: 10.1111/coa.13593)

Wei, Q., Young, J., Holle, A., Li, J., Bieback, K., Inman, G., Spatz, J. P., Cavalcanti-Adam, E. A. (2020) Soft hydrogels for balancing cell proliferation and differentiation. ACS Biomaterials Science and Engineering, 6, pp. 4687-4701. (doi: 10.1021/acsbiomaterials.0c00854)

Wei, Q., Holle, A., Liu, J., Posa, F., Biagioni, F., Croci, O., Benk, A. S., Young, J., Noureddine, F., Deng, J., Zhang, M., Inman, G. J., Spatz, J. P., Campaner, S., Cavalcanti‐Adam, E. A. (2020) BMP‐2 signaling and mechanotransduction synergize to drive osteogenic differentiation via YAP/TAZ. Advanced Science, 7, (doi: 10.1002/advs.201902931)

Hay, L. K., Paterson, C., McLoone, P., Miguel-Chumacero, E., Valentine, R., Currie, S., Grose, D., Schipani, S., Wilson, C., Nixon, I., James, A., Duffton, A. (2020) Analysis of dose using CBCT and synthetic CT during head and neck radiotherapy: A single centre feasibility study. Technical Innovations and Patient Support in Radiation Oncology, 14, pp. 21-29. (doi: 10.1016/j.tipsro.2020.02.004)

2019

Paterson, C., Thomson, M., Caldwell, B., Young, R., McLean, A., Porteous, S., Clark, S., Messow, C. M., Kean, S., Grose, D., Lamb, C., Rizwannullah, M., James, A., Schipani, S., Wilson, C., Rulach, R., Jones, R. (2019) Radiotherapy-induced xerostomia: a randomised, double-blind, controlled trial of Visco-ease™ oral spray compared with placebo in patients with cancer of the head and neck. British Journal of Oral and Maxillofacial Surgery, 57, pp. 1119-1125. (doi: 10.1016/j.bjoms.2019.10.300)

Tsim, S., Paterson, S., Cartwright, D., Fong, C. J., Alexander, L., Kelly, C., Holme, J., Evison, M., Blyth, K. G. (2019) Baseline predictors of negative and incomplete pleural cytology in patients with suspected pleural malignancy - Data supporting 'Direct to LAT' in selected groups. Lung Cancer, 133, pp. 123-129. (doi: 10.1016/j.lungcan.2019.05.017)

Badshah, I.I., Brown, S., Weibel, L., Rose, A., Way, B., Sebire, N., Inman, G., Harper, J., O'Shaughnessy, R.F.L. (2019) Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts. British Journal of Dermatology, 180, pp. 1135-1149. (doi: 10.1111/bjd.17352)

Spender, L. C., Ferguson, G. J., Hughes, G. D., Davies, B. R., Goldberg, F. W., Herrera, B., Taylor, R. G., Strathearn, L. S., Sansom, O. J., Barry, S. T., Inman, G. I. (2019) Preclinical evaluation of AZ12601011 and AZ12799734, inhibitors of transforming growth factor β superfamily type 1 receptors. Molecular Pharmacology, 95, pp. 222-234. (doi: 10.1124/mol.118.112946)

Hassan, S., Purdie, K. J., Wang, J., Harwood, C. A., Proby, C. M., Pourreyron, C., Mladkova, N., Nagano, A., Dhayade, S., Athineos, D., Caley, M., Mannella, V., Blyth, K., Inman, G. J., Leigh, I. M. (2019) A unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing. International Journal of Molecular Sciences, 20, (doi: 10.3390/ijms20143428)

2018

Inman, G. J., Wang, J., Nagano, A., Alexandrov, L. B., Purdie, K. J., Taylor, R. G., Sherwood, V., Thomson, J., Hogan, S., Spender, L. C., South, A. P., Stratton, M., Chelala, C., Harwood, C. A., Proby, C. M., Leigh, I. M. (2018) The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature. Nature Communications, 9, (doi: 10.1038/s41467-018-06027-1)

Purdie, K. J., Proby, C. M., Rizvi, H., Griffin, H., Doorbar, J., Sommerlad, M., Feltkamp, M. C., Meijden, E. V. d., Inman, G. J., South, A. P., Leigh, I. M., Harwood, C. A. (2018) The role of human papillomaviruses and polyomaviruses in BRAF-inhibitor induced cutaneous squamous cell carcinoma and benign squamoproliferative lesions. Frontiers in Microbiology, 9, (doi: 10.3389/fmicb.2018.01806)

Rose, A. M., Spender, L. C., Stephen, C., Mitchell, A., Rickaby, W., Bray, S., Evans, A. T., Dayal, J., Purdie, K. J., Harwood, C. A., Proby, C. M., Leigh, I. M., Coates, P. J., Inman, G. j. (2018) Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma. Oncotarget, 9, pp. 14552-14566. (doi: 10.18632/oncotarget.24545)

Hurst, L. A., Dunmore, B. J., Long, L., Crosby, A., Al-Lamki, R., Deighton, J., Southwood, M., Yang, X., Nikolic, M. Z., Herrera, B., Inman, G. J., Bradley, J. R., Rana, A. A., Upton, P. D., Morrell, N. W. (2018) TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nature Communications, 8, (doi: 10.1038/ncomms14079)

2017

Cammareri, P., Vincent, D. F., Hodder, M. C., Ridgway, R. A., Murgia, C., Nobis, M., Campbell, A. D., Varga, J., Huels, D. J., Subramani, C., Prescott, K. L.H., Nixon, C., Hedley, A., Barry, S. T., Greten, F. R., Inman, G. J., Sansom, O. J. (2017) TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis. Cell Death and Differentiation, 24, pp. 1681-1693. (doi: 10.1038/cdd.2017.92)

Phillips, T. J. et al. (2017) Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development. Scientific Reports, 7, (doi: 10.1038/s41598-017-06300-1)

Spender, L. C., Inman, G. J. (2017) Targeting BRAF-mutant tumours with TGFBR1 inhibitors. Aging, 9, pp. 5-6. (doi: 10.18632/aging.101169)

Rose, A. M., Sansom, O. J., Inman, G. J. (2017) Loss of TGF-β signaling drives cSCC from skin stem cells – More evidence. Cell Cycle, 16, pp. 386-387. (doi: 10.1080/15384101.2016.1259892)

Postgraduate research students

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• Exploration as to how to overcome cancers that are resistant to radiotherapy.

• Generation of models that inform response-based adaptations, individually optimized delivery and enable biological monitoring to provide decision support to clinicians.

• Investigation into role of cell death as a key tumour suppression mechanism, which is inhibited in order for cancer to develop.

• One of the 7 CRUK RadNet Glasgow focus groups. Main themes are translational studies, epidemiology studies focussed on inequalities and clinical trials with ongoing studies ranging from lab-based projects to population level studies. Research projects include:

  • BARITONE – adaptive radiotherapy for advanced oropharyngeal cancer, using MRI scans during treatment - Radiotherapy failure after treatment of oropharyngeal cancer – most patients who have an HPV positive oropharyngeal cancer do very well after treatment however a small subset of these patients go on to develop recurrence of their cancer. This study will examine these patients in more detail to better understand why these patients develop recurrence.
  • The impact of the covid pandemic on head and neck cancer – the pandemic had a significant impact on UK healthcare. This study aims to look at the impact on head and neck cancer patients. - HEADSpAcE – Head and Neck Cancer in South America and Europe. This EU funded, WHO-IARC coordinated study is building a multicentre cohort investigating factors associated with late-stage head and neck cancer.